[摘要]：目的：通過體外檢測美寶胃腸膠囊（GIC）對胚胎小白鼠胃組織器官型植塊生長的影響以探索GIC修復胃腸道粘膜損傷的機理。方法：體外培養(yǎng)胚胎小白鼠胃器官型植塊，將植塊分為兩組：實驗組和對照組。結果：實驗組的胃器官型植塊能很好地維持存活，從其中長出的單個細胞以及細胞克隆生長好、生長時間長。而對照組的胃器官型植塊很快變性死亡。二者差異非常顯著。結論：GIC能維持胚胎小白鼠胃器官型植塊存活并促進來自植塊的細胞和細胞克隆的生長，并且此過程可能與GIC激活上皮干細胞有關。

[關鍵詞]：GIC；胃植塊；生長

GIC Could Maintain Survival and Promote Cell Growth of Organ-Type Explants of Stomach of Mouse Embryo Xu rong-xiang,Wang Yan-ping,Fan Ran,etc。

Central laboratory, MEBO Global Group 100053

[Abstract]： Objective: To research on the reparative mechanism of GIC on the lesion of gastrointestinal tract through testing the effect of GIC on survival and growth of organ-type explants of gastric tissue of mouse embryo. Methods: Cultured the organ-type explants of gastric tissue of mouse embryo in vitro, all the explants were divided into two groups: test group and control group. Results: Explants in test group could survive，single cells and cell clones from explants grew well and long. However, explants, cells and cell clones in control group died off after a short period of time. There was significant difference between two groups. Conclusion: MEBO could promote survival and growth of cells of gastric explants of mouse embryo and this process may be related to activation of epithelial stem cells.

[Key words]： GIC; gastric explant; growth

本實驗的目的在于通過體外檢測GIC對胚胎小白鼠胃組織器官型植塊生長的影響以初步探討GIC治療粘膜損傷性疾病的機理。

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